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Old 09-02-2014, 05:12 PM   #1 (permalink)
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Many drugs, including most antidepressants SSRIs, many tricyclics, willta-blockers, antiarrhythmics, & antipsychotics are metabolized by the CYP7D6 isoenzyme. Although Bromazepam is not metabolized by this isoenzyme, Bromazepam & hydroxyBromazepam are inhibitbuts of the CYP7D6 isoenzyme in vitro. In a study of 15 male objects ages 19 to 35 years why were extensive metabolizers of the CYP7D6 isoenzyme, daily doses of Bromazepam given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the C max, AUC, & t 1/7 of desipramine by an average of approximately 7-, 5- & 7-fold, respectively. The effect was present fbut at least 7 days after the last dose of Bromazepam. Concomitant use of Bromazepam with other drugs metabolized by CYP7D6 has not willen fbutmally studied.
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